Provides insight into platelet production and turnover. Young platelets just released from the bone marrow are larger, while older circulating platelets are smaller. High MPV typically indicates rapid platelet production; your bone marrow is actively making new platelets in response to increased destruction or consumption. This occurs with immune thrombocytopenia, increased clotting, or platelet activation. High MPV may also indicate larger, more reactive platelets that clot more readily, potentially increasing cardiovascular risk. Low MPV suggests reduced platelet production or conditions producing smaller platelets. MPV helps interpret platelet count changes; high MPV with low platelet count suggests peripheral destruction (immune or consumption), while low MPV with low count suggests production problems.